The Old firm derby between Rangers and Celtic takes centre stage in the SPL on Saturday.
Elsewhere Aberdeen welcome Hearts to Pittodrie with both sides battling to boost their European aspirations.
Dundee United will be aiming to cement their spot in third place when they entertain Falkirk to Tannadice.
Hamilton will be looking to climb off the bottom of the table when they travel to St Mirren.
Motherwell are in desperate need of a morale-boosting victory as they welcome fellow strugglers Inverness to Fir Park.
Hibernian will be seeking to keep pace with the leading pack Kilmarnock make the trip to Edinburgh.
Aberdeen v Hearts
Aberdeen midfielder Derek Young should be fit for Saturday's clash with Hearts after missing the win at Inverness through injury.
Jamie Smith and Bertrand Bossu are both pushing for places in the squad after recovering from calf strains.
The Dons, who have won their last four games at Pittodrie, will still be without long term absentees Tommy Wright (Achilles) and Stuart Duff (knee).
Hearts manager Csaba Laszlo is confident Andy Driver, Bruno Aguiar and Ruben Palazuelos will all be fit for the clash.
The trio all picked up knocks in the weekend's goalless draw with Dundee United, but they should be fit to play.
Uganda international David Obua faces at least four weeks on the sidelines with a groin problem, while strikers Juho Makela (ankle) and Mike Tullberg (thigh) are also out.
Dundee United v Falkirk
Falkirk manager John Hughes will welcome back defender Jackie McNamara from suspension for the trip to Dundee United on Saturday.
The former Scotland international has missed the last two defeats to his former clubs Aberdeen and Celtic.
Forward Michael Higdon should also return after a flu bug kept him out of the 3-0 loss to Celtic, while striker Carl Finnigan and left-back Tam Scobbie are pushing for starts following their returns to fitness.
But young defender Brian Allison remains absent (foot) despite being back in training.
Dundee United have a doubt over striker Francisco Sandaza for the clash at Tannadice.
The Spaniard has been plagued by a foot problem for the last month and, while his condition is improving, manager Craig Levein may opt to give him another week's rest.
With Irishman Jon Daly in good form and Warren Feeney also in the squad, Levein has options available to him.
Garry Kenneth will continue at the back alongside Lee Wilkie.
Hibernian v Kilmarnock
Hibernian could welcome back striker Derek Riordan and midfielder Dean Shiels for Saturday's game with Kilmarnock.
Riordan missed last weekend's 1-0 defeat at Rangers with a cut leg and Shiels has been absent for the last three games with an ankle injury.
Both have returned to first-team training and may come into contention for starting slots as the Easter Road side seek a boost ahead of the forthcoming league and cup double-header against arch-rivals Hearts.
Kilmarnock are hopeful of having four players back from injury for the clash.
Willie Gibson, Mehdi Taouil, Danny Invincibile and Simon Ford have all returned to training and their fitness will be assessed ahead of the game.
However, Frazer Wright (hamstring) has joined David Lilley, Ryan O'Leary and Allan Johnston on the sidelines.
Motherwell v Inverness
Ian Black and Russell Duncan are both doubts for Inverness' crunch basement battle at Motherwell.
The central midfield pair picked up knocks in Saturday's 3-0 defeat to Aberdeen; Duncan has a slight groin strain, while Black is nursing a hamstring injury.
Rory McAllister remains on the sidelines after sustaining ankle ligament damage in training earlier this month.
Motherwell manager Mark McGhee could be hit by more withdrawals for the clash.
Captain Stephen Craigan (groin) and striker David Clarkson (hand) remain sidelined.
McGhee is waiting on a doctor's report on Bob Malcolm, Steven McGarry, Jamie Murphy and Stephen Hughes, who have all missed training this week through sickness.
Rangers v Celtic
Rangers will be aiming to cut the gap on leaders Celtic when they welcome Gordon Strachan's side to Ibrox in the second Old Firm derby of the season.
Rangers defender Madjid Bougherra is facing a late fitness test ahead of the league encounter with Celtic.
Maurice Edu has recovered from an ankle injury, while Chris Burke has shaken off the flu and striker Kenny Miller is fine despite a slight knock.
Celtic trio Stephen McManus, Paul Hartley and Barry Robson are back in contention for the trip to Ibrox.
Striker Jan Vennegoor of Hesselink has also returned to training but will not be rushed back to action.
St Mirren v Hamilton
Hamilton boss Billy Reid is sweating over the fitness of Mark McLaughlin ahead of Saturday's trip to St Mirren.
Defender McLaughlin came off against Motherwell at the weekend with a back strain and is being monitored.
Goalkeeper Tomas Cerny has recovered after suffering concussion while skipper Alex Neil plays his last game before commencing a two-match ban for going through the points threshold.
St Mirren are hopeful Jim Hamilton will be fit for the clash.
The striker picked up a knock in the 1-0 win over Kilmarnock at the weekend.
Stephen O'Donnell (knee), Will Haining (foot) and Steven Robb (shoulder) remain on the sidelines.
Elsewhere Aberdeen welcome Hearts to Pittodrie with both sides battling to boost their European aspirations.
Dundee United will be aiming to cement their spot in third place when they entertain Falkirk to Tannadice.
Hamilton will be looking to climb off the bottom of the table when they travel to St Mirren.
Motherwell are in desperate need of a morale-boosting victory as they welcome fellow strugglers Inverness to Fir Park.
Hibernian will be seeking to keep pace with the leading pack Kilmarnock make the trip to Edinburgh.
Aberdeen v Hearts
Aberdeen midfielder Derek Young should be fit for Saturday's clash with Hearts after missing the win at Inverness through injury.
Jamie Smith and Bertrand Bossu are both pushing for places in the squad after recovering from calf strains.
The Dons, who have won their last four games at Pittodrie, will still be without long term absentees Tommy Wright (Achilles) and Stuart Duff (knee).
Hearts manager Csaba Laszlo is confident Andy Driver, Bruno Aguiar and Ruben Palazuelos will all be fit for the clash.
The trio all picked up knocks in the weekend's goalless draw with Dundee United, but they should be fit to play.
Uganda international David Obua faces at least four weeks on the sidelines with a groin problem, while strikers Juho Makela (ankle) and Mike Tullberg (thigh) are also out.
Dundee United v Falkirk
Falkirk manager John Hughes will welcome back defender Jackie McNamara from suspension for the trip to Dundee United on Saturday.
The former Scotland international has missed the last two defeats to his former clubs Aberdeen and Celtic.
Forward Michael Higdon should also return after a flu bug kept him out of the 3-0 loss to Celtic, while striker Carl Finnigan and left-back Tam Scobbie are pushing for starts following their returns to fitness.
But young defender Brian Allison remains absent (foot) despite being back in training.
Dundee United have a doubt over striker Francisco Sandaza for the clash at Tannadice.
The Spaniard has been plagued by a foot problem for the last month and, while his condition is improving, manager Craig Levein may opt to give him another week's rest.
With Irishman Jon Daly in good form and Warren Feeney also in the squad, Levein has options available to him.
Garry Kenneth will continue at the back alongside Lee Wilkie.
Hibernian v Kilmarnock
Hibernian could welcome back striker Derek Riordan and midfielder Dean Shiels for Saturday's game with Kilmarnock.
Riordan missed last weekend's 1-0 defeat at Rangers with a cut leg and Shiels has been absent for the last three games with an ankle injury.
Both have returned to first-team training and may come into contention for starting slots as the Easter Road side seek a boost ahead of the forthcoming league and cup double-header against arch-rivals Hearts.
Kilmarnock are hopeful of having four players back from injury for the clash.
Willie Gibson, Mehdi Taouil, Danny Invincibile and Simon Ford have all returned to training and their fitness will be assessed ahead of the game.
However, Frazer Wright (hamstring) has joined David Lilley, Ryan O'Leary and Allan Johnston on the sidelines.
Motherwell v Inverness
Ian Black and Russell Duncan are both doubts for Inverness' crunch basement battle at Motherwell.
The central midfield pair picked up knocks in Saturday's 3-0 defeat to Aberdeen; Duncan has a slight groin strain, while Black is nursing a hamstring injury.
Rory McAllister remains on the sidelines after sustaining ankle ligament damage in training earlier this month.
Motherwell manager Mark McGhee could be hit by more withdrawals for the clash.
Captain Stephen Craigan (groin) and striker David Clarkson (hand) remain sidelined.
McGhee is waiting on a doctor's report on Bob Malcolm, Steven McGarry, Jamie Murphy and Stephen Hughes, who have all missed training this week through sickness.
Rangers v Celtic
Rangers will be aiming to cut the gap on leaders Celtic when they welcome Gordon Strachan's side to Ibrox in the second Old Firm derby of the season.
Rangers defender Madjid Bougherra is facing a late fitness test ahead of the league encounter with Celtic.
Maurice Edu has recovered from an ankle injury, while Chris Burke has shaken off the flu and striker Kenny Miller is fine despite a slight knock.
Celtic trio Stephen McManus, Paul Hartley and Barry Robson are back in contention for the trip to Ibrox.
Striker Jan Vennegoor of Hesselink has also returned to training but will not be rushed back to action.
St Mirren v Hamilton
Hamilton boss Billy Reid is sweating over the fitness of Mark McLaughlin ahead of Saturday's trip to St Mirren.
Defender McLaughlin came off against Motherwell at the weekend with a back strain and is being monitored.
Goalkeeper Tomas Cerny has recovered after suffering concussion while skipper Alex Neil plays his last game before commencing a two-match ban for going through the points threshold.
St Mirren are hopeful Jim Hamilton will be fit for the clash.
The striker picked up a knock in the 1-0 win over Kilmarnock at the weekend.
Stephen O'Donnell (knee), Will Haining (foot) and Steven Robb (shoulder) remain on the sidelines.
