Celtic have the chance to stretch their lead at the top of the SPL to six points on Saturday and put pressure on trailing Rangers.
The Hoops take on Hamilton Academicals, who are looking for a first win in five games after suffering a lull in their New Year resurgence.
Gordon Strachan and his charges will be hoping for a fairly straightforward win at Celtic Park given their opponent's recent form, but matters may be slightly more complicated for Rangers on Sunday.
Walter Smith's boys head to bottom of the league Falkirk,with the Bairns knowing that a win will guarantee to lift them out of the relegation spot.
This is down to the fact that at least one of relegation candidates Inverness and St Mirren are set drop points when they clash on the Saturday, making the result of great interest to the futures of almost half of the SPL's clubs.
One of those clubs, Kilmarnock, will be also be hoping to expose any sense of complacency from third-placed Hearts and sneak a vital win over their opponents this weekend.
Elsewhere, Dundee United can move into fourth place with a win over Hibernian in the early kick-off, before Aberdeen travel to Motherwell knowing whether their task will be to try and take back fourth, or to extend the gap with a win.
Celtic v Hamilton
Aiden McGeady has declared himself fit for Celtic's Clydesdale Bank Premier League clash with Hamilton at Parkhead.
The Republic of Ireland midfielder missed the midweek World Cup qualifier in Italy with a knee injury but reported fit to the club's Lennoxtown training camp.
Skipper Stephen McManus - who played for Scotland against Iceland nursing an ankle problem - did not train but is expected to be fit, while defender Glenn Loovens (calf) and Paddy McCourt (hamstring) are back in contention.
For the Accies, new boys Derek Asamoah and Christy Fagan go straight into the squad.
The strike pair joined the club this week until the end of the season, with manager Billy Reid's injury worries showing little sign of abating.
Top scorer Richard Offiong (knee) could face another three weeks on the sidelines and fellow forward Kenny Deuchar is struggling with a calf strain, but defenders Brian Easton (hamstring) and Trent McClenahan (hernia) may return despite the latter needing an operation.
Goalkeeper Tomas Cerny joins Simon Mensing on the suspension list.
Dundee Utd v Hibernian
Dundee United will have Northern Ireland hero Warren Feeney available for the game with Hibs.
Feeney played for his country against Poland and Slovenia in World Cup qualifiers, prompting manager Craig Levein to fear for his physical condition.
But the 28-year-old has returned to Tannadice ready to play and Morgaro Gomis, who was on international duty with Senegal, is also fully fit.
Scott Robertson remains on the sidelines with a groin injury, while Darren Dods has been nursing a calf problem.
Newly crowned manager of the month Mixu Paatelainen has the luxury of a full Hibernian squad for the trip to Dundee United.
Sol Bamba is back from suspension, while Lewis Stevenson has shrugged off the ankle problem that forced him out of Scotland Under-21 duty this week.
Meanwhile, Ian Murray is in line for his first start in almost three months after suffering a groin injury which required surgery.
Hearts v Kilmarnock
Hearts goalkeeper Jamie MacDonald is struggling to be fit for the visit of Kilmarnock due to a hand ligament injury, but Janos Balogh is eligible following suspension.
Midfielder Laryea Kingston is still unavailable because of a hamstring problem, although Andy Driver is fit after a similar injury.
Adrian Mrowiec and Jason Thomson are both doubts after picking up knocks.
Kilmarnock will be without Craig Bryson through suspension meaning the midfielder will have watch on along with Frazer Wright, who is still out with a knee injury.
Longer-term casualties James Fowler and Allan Russell both remain on the sidelines.
Inverness CT v St Mirren
Inverness goalkeeper Michael Fraser is in line to make his first SPL start since November against St Mirren.
The 25-year-old, who signed a pre-contract agreement with Motherwell in January, comes in from the cold in place of the suspended Ryan Esson.
Kieran Wilson, 17, will provide back-up, with third-choice keeper Andy McNulty on loan at Elgin City and fourth choice Kyle Allison out with a broken jaw.
St Mirren's injury list has grown with the news that Dennis Wyness will miss the visit to his former club after damaging a stomach muscle, while Hugh Murray remains suspended.
Chris Smith underwent surgery on his damaged cruciate ligament this week while Tom Brighton, Steven Robb, Stephen O'Donnell and Franco Miranda remain on the sidelines.
Motherwell v Aberdeen
Motherwell will give Stephen Craigan a fitness test on Saturday morning ahead of the clash.
The Well skipper missed Northern Ireland's win over Slovenia on Wednesday with a calf injury, while boss Mark McGhee will definitely be without Maros Klimpl as he serves a one-match ban.
Lee Miller returns to the Aberdeen attack for the trip south after missing the last month with a hamstring injury.
However fellow strikers Darren Mackie (hamstring) and Tommy Wright (bug) are both unavailable for the match.
Midfielder Mark Kerr also misses out through suspension. Scott Severin is likely to replace him in central midfield with Lee Mair - who has recovered from injury - returning to the heart of the defence.
Sunday
Falkirk v Rangers
Falkirk manager John Hughes has no major injury concerns to worry about, and the Bairns could welcome back Steve Lovell after nearly a month out of the side.
The striker picked up an injury during the Scottish Cup tie with Inverness last month, but could be risked despite a lack of match fitness.
In the Rangers camp, amidst the controversy of Barry Ferguson and Allan McGregor's suspensions from the squad, the club are set for a triple fitness boost at the heart of their defence for Sunday's trip to Falkirk.
The duo were sent packing from domestic duty and Ferguson stripped of the captaincy after boss Walter Smith deemed their behaviour while on international leave to be unacceptable. Kenny Miller is out through injury.
But on a brighter note, David Weir, Madjid Bougherra and Kirk Broadfoot are set to be in contention for a start after they all missed the damaging 2-2 draw with Hearts due to injury.
The Hoops take on Hamilton Academicals, who are looking for a first win in five games after suffering a lull in their New Year resurgence.
Gordon Strachan and his charges will be hoping for a fairly straightforward win at Celtic Park given their opponent's recent form, but matters may be slightly more complicated for Rangers on Sunday.
Walter Smith's boys head to bottom of the league Falkirk,with the Bairns knowing that a win will guarantee to lift them out of the relegation spot.
This is down to the fact that at least one of relegation candidates Inverness and St Mirren are set drop points when they clash on the Saturday, making the result of great interest to the futures of almost half of the SPL's clubs.
One of those clubs, Kilmarnock, will be also be hoping to expose any sense of complacency from third-placed Hearts and sneak a vital win over their opponents this weekend.
Elsewhere, Dundee United can move into fourth place with a win over Hibernian in the early kick-off, before Aberdeen travel to Motherwell knowing whether their task will be to try and take back fourth, or to extend the gap with a win.
Celtic v Hamilton
Aiden McGeady has declared himself fit for Celtic's Clydesdale Bank Premier League clash with Hamilton at Parkhead.
The Republic of Ireland midfielder missed the midweek World Cup qualifier in Italy with a knee injury but reported fit to the club's Lennoxtown training camp.
Skipper Stephen McManus - who played for Scotland against Iceland nursing an ankle problem - did not train but is expected to be fit, while defender Glenn Loovens (calf) and Paddy McCourt (hamstring) are back in contention.
For the Accies, new boys Derek Asamoah and Christy Fagan go straight into the squad.
The strike pair joined the club this week until the end of the season, with manager Billy Reid's injury worries showing little sign of abating.
Top scorer Richard Offiong (knee) could face another three weeks on the sidelines and fellow forward Kenny Deuchar is struggling with a calf strain, but defenders Brian Easton (hamstring) and Trent McClenahan (hernia) may return despite the latter needing an operation.
Goalkeeper Tomas Cerny joins Simon Mensing on the suspension list.
Dundee Utd v Hibernian
Dundee United will have Northern Ireland hero Warren Feeney available for the game with Hibs.
Feeney played for his country against Poland and Slovenia in World Cup qualifiers, prompting manager Craig Levein to fear for his physical condition.
But the 28-year-old has returned to Tannadice ready to play and Morgaro Gomis, who was on international duty with Senegal, is also fully fit.
Scott Robertson remains on the sidelines with a groin injury, while Darren Dods has been nursing a calf problem.
Newly crowned manager of the month Mixu Paatelainen has the luxury of a full Hibernian squad for the trip to Dundee United.
Sol Bamba is back from suspension, while Lewis Stevenson has shrugged off the ankle problem that forced him out of Scotland Under-21 duty this week.
Meanwhile, Ian Murray is in line for his first start in almost three months after suffering a groin injury which required surgery.
Hearts v Kilmarnock
Hearts goalkeeper Jamie MacDonald is struggling to be fit for the visit of Kilmarnock due to a hand ligament injury, but Janos Balogh is eligible following suspension.
Midfielder Laryea Kingston is still unavailable because of a hamstring problem, although Andy Driver is fit after a similar injury.
Adrian Mrowiec and Jason Thomson are both doubts after picking up knocks.
Kilmarnock will be without Craig Bryson through suspension meaning the midfielder will have watch on along with Frazer Wright, who is still out with a knee injury.
Longer-term casualties James Fowler and Allan Russell both remain on the sidelines.
Inverness CT v St Mirren
Inverness goalkeeper Michael Fraser is in line to make his first SPL start since November against St Mirren.
The 25-year-old, who signed a pre-contract agreement with Motherwell in January, comes in from the cold in place of the suspended Ryan Esson.
Kieran Wilson, 17, will provide back-up, with third-choice keeper Andy McNulty on loan at Elgin City and fourth choice Kyle Allison out with a broken jaw.
St Mirren's injury list has grown with the news that Dennis Wyness will miss the visit to his former club after damaging a stomach muscle, while Hugh Murray remains suspended.
Chris Smith underwent surgery on his damaged cruciate ligament this week while Tom Brighton, Steven Robb, Stephen O'Donnell and Franco Miranda remain on the sidelines.
Motherwell v Aberdeen
Motherwell will give Stephen Craigan a fitness test on Saturday morning ahead of the clash.
The Well skipper missed Northern Ireland's win over Slovenia on Wednesday with a calf injury, while boss Mark McGhee will definitely be without Maros Klimpl as he serves a one-match ban.
Lee Miller returns to the Aberdeen attack for the trip south after missing the last month with a hamstring injury.
However fellow strikers Darren Mackie (hamstring) and Tommy Wright (bug) are both unavailable for the match.
Midfielder Mark Kerr also misses out through suspension. Scott Severin is likely to replace him in central midfield with Lee Mair - who has recovered from injury - returning to the heart of the defence.
Sunday
Falkirk v Rangers
Falkirk manager John Hughes has no major injury concerns to worry about, and the Bairns could welcome back Steve Lovell after nearly a month out of the side.
The striker picked up an injury during the Scottish Cup tie with Inverness last month, but could be risked despite a lack of match fitness.
In the Rangers camp, amidst the controversy of Barry Ferguson and Allan McGregor's suspensions from the squad, the club are set for a triple fitness boost at the heart of their defence for Sunday's trip to Falkirk.
The duo were sent packing from domestic duty and Ferguson stripped of the captaincy after boss Walter Smith deemed their behaviour while on international leave to be unacceptable. Kenny Miller is out through injury.
But on a brighter note, David Weir, Madjid Bougherra and Kirk Broadfoot are set to be in contention for a start after they all missed the damaging 2-2 draw with Hearts due to injury.
