Rangers can jump to the summit of the SPL for at least 24 hours if they beat Kilmarnock at Ibrox on Saturday.
Walter Smith's side will fancy their chances against Jim Jefferies' charges who have not won in their last six SPL games.
If Gers do win, they will go a point clear of Old Firm rivals Celtic, who do not play at Motherwell until Sunday.
Gordon Strachan's leaders will be looking to get back to winning ways in the game - which is the SPL's only Sunday clash - after drawing their last two league encounters.
But it will not be easy against a Well side who are the top flight's form team, being unbeaten in seven games.
But if the top two do slip up, third-placed Hearts will be hoping to close the gap when they entertain St Mirren at Tynecastle.
Csaba Laszlo's side will be confident against opponents who are in poor form - failing to win in five league games - to sit third from bottom in the table.
Fifth-placed Aberdeen can leapfrog fourth-placed Dundee United with victory at Pittodrie.
Both sides will be looking to return to winning ways as the Dons have lost their last two league games, while the Terrors have not won in two SPL encounters.
Down at the bottom, Inverness have shown much improved form under new boss Terry Butcher - holding both Celtic and Dundee United to draws - with a Scottish Cup win over Kilmarnock sandwiched in between.
Butcher's charges take on Hibernian - who have drawn their last two league games - aiming to close the current four-point gap to safety.
Second-from-bottom Falkirk are unbeaten in three SPL games and also face a home tie with Hamilton, who will be looking to put a 1-0 away reverse to Motherwell behind them after they had won their four previous league encounters.
Aberdeen v Dundee United
Aberdeen welcome Zander Diamond back to their squad for the clash with Dundee United.
The central defender has made a quicker than expected recovery from an Achilles injury and is available to face Craig Levein's men.
Striker Darren Mackie has also recovered from a hamstring injury after missing the midweek win over East Fife in the Homecoming Scottish Cup, but Andrew Considine (groin), Gary McDonald (hip) and Jamie Smith (calf) remain on the sidelines.
For Dundee United, midfielder Prince Buaben will be available for the game.
The Ghana international was a doubt after picking up an ankle knock against Inverness last weekend but trained on Friday and has been passed fit to play.
Skipper Lee Wilkie has also shrugged off a knee complaint, but the journey to Pittodrie has come too soon for James Wesolowski, who is still short of match sharpness and will not feature.
Falkirk v Hamilton
Falkirk have been decimated by injuries for the visit of Hamilton.
Neil McCann, Dean Holden (both hamstring), Steve Lovell (knee) and Jackie McNamara (back) are all out.
Long-term absentees Tam Scobbie (groin), Gerard Aafjes (knee) and Kevin McBride (back) are also set to miss the clash.
Hamilton have no fresh injury concerns for this game.
Defender David Elebert has returned to first-team training following the torn hamstring that sidelined him for the past few weeks but this game comes too soon for him.
Accies' only other absentee is midfielder Mark Corcoran, who is recovering from hip surgery.
Hearts v St Mirren
Hearts manager Laszlo will be without midfielder Laryea Kingston for the visit of St Mirren.
The Ghanaian has been back in his homeland for treatment on a troublesome hamstring injury and misses out.
Andrew Driver, Janos Balogh and Christos Karipidis were all sick earlier in the week but should shake off bugs to feature.
Marius Zaliukas continues his four-match suspension, while Mike Tullberg is a long-term absentee.
St Mirren welcome Mo Camara back after the former Celtic left-back was ineligible for Thursday night's Scottish Cup win over Motherwell.
Steven Robb, Stephen O'Donnell and Franco Miranda are still sidelined.
Inverness CT v Hibernian
Eric Odhiambo and Dougie Imrie will lead the Inverness attack again for this game.
Brian Kerr and Roy McBain are likely to replace the suspended Ian Black and Russell Duncan in the hosts' midfield.
Hibernian, meanwhile, have been boosted by the news captain Rob Jones has recovered from a stomach bug in time for the game.
Scotland striker Steven Fletcher is also back to full fitness after being left on the bench at Kilmarnock last weekend following precautionary scans on a knee injury.
Fellow forward Colin Nish and midfielder Denes Rosa have shrugged off knocks to make the trip north, with only full-backs Ian Murray and Kevin McCann missing out.
Rangers v Kilmarnock
Lee McCulloch has been ruled out of Rangers' clash against Kilmarnock.
The midfielder suffered a calf injury during the midweek Scottish Cup win at Forfar and could be sidelined for a couple of weeks.
DaMarcus Beasley was also injured in the clash at Station Park but has resumed training and should have recovered from the shin knock in time for the game.
Kilmarnock, meanwhile, are boosted by the return of Kevin Kyle for the trip to Ibrox as the striker returns from suspension.
But David Fernandez is still banned, while boss Jim Jefferies will make a late decision on Frazer Wright and Mehdi Taouil but is hopeful both will be fit.
Sunday
Motherwell v Celtic
Cillian Sheridan is unavailable for Motherwell's clash against Celtic as the Hoops will not allow their on-loan striker to play against them.
Paul Quinn's two-match ban does not come into effect until the following weekend so Mark McGhee has an almost-full squad to choose from.
Celtic midfielder Barry Robson will miss the trip as he is set to have an operation on a groin injury next week.
The Scotland midfielder has battled with the groin problem this season and missed the game against Rangers at Celtic Park last week after the injury flared up again in training.
Shaun Maloney will also be missing on Sunday as the striker is still out with a hamstring injury.
Walter Smith's side will fancy their chances against Jim Jefferies' charges who have not won in their last six SPL games.
If Gers do win, they will go a point clear of Old Firm rivals Celtic, who do not play at Motherwell until Sunday.
Gordon Strachan's leaders will be looking to get back to winning ways in the game - which is the SPL's only Sunday clash - after drawing their last two league encounters.
But it will not be easy against a Well side who are the top flight's form team, being unbeaten in seven games.
But if the top two do slip up, third-placed Hearts will be hoping to close the gap when they entertain St Mirren at Tynecastle.
Csaba Laszlo's side will be confident against opponents who are in poor form - failing to win in five league games - to sit third from bottom in the table.
Fifth-placed Aberdeen can leapfrog fourth-placed Dundee United with victory at Pittodrie.
Both sides will be looking to return to winning ways as the Dons have lost their last two league games, while the Terrors have not won in two SPL encounters.
Down at the bottom, Inverness have shown much improved form under new boss Terry Butcher - holding both Celtic and Dundee United to draws - with a Scottish Cup win over Kilmarnock sandwiched in between.
Butcher's charges take on Hibernian - who have drawn their last two league games - aiming to close the current four-point gap to safety.
Second-from-bottom Falkirk are unbeaten in three SPL games and also face a home tie with Hamilton, who will be looking to put a 1-0 away reverse to Motherwell behind them after they had won their four previous league encounters.
Aberdeen v Dundee United
Aberdeen welcome Zander Diamond back to their squad for the clash with Dundee United.
The central defender has made a quicker than expected recovery from an Achilles injury and is available to face Craig Levein's men.
Striker Darren Mackie has also recovered from a hamstring injury after missing the midweek win over East Fife in the Homecoming Scottish Cup, but Andrew Considine (groin), Gary McDonald (hip) and Jamie Smith (calf) remain on the sidelines.
For Dundee United, midfielder Prince Buaben will be available for the game.
The Ghana international was a doubt after picking up an ankle knock against Inverness last weekend but trained on Friday and has been passed fit to play.
Skipper Lee Wilkie has also shrugged off a knee complaint, but the journey to Pittodrie has come too soon for James Wesolowski, who is still short of match sharpness and will not feature.
Falkirk v Hamilton
Falkirk have been decimated by injuries for the visit of Hamilton.
Neil McCann, Dean Holden (both hamstring), Steve Lovell (knee) and Jackie McNamara (back) are all out.
Long-term absentees Tam Scobbie (groin), Gerard Aafjes (knee) and Kevin McBride (back) are also set to miss the clash.
Hamilton have no fresh injury concerns for this game.
Defender David Elebert has returned to first-team training following the torn hamstring that sidelined him for the past few weeks but this game comes too soon for him.
Accies' only other absentee is midfielder Mark Corcoran, who is recovering from hip surgery.
Hearts v St Mirren
Hearts manager Laszlo will be without midfielder Laryea Kingston for the visit of St Mirren.
The Ghanaian has been back in his homeland for treatment on a troublesome hamstring injury and misses out.
Andrew Driver, Janos Balogh and Christos Karipidis were all sick earlier in the week but should shake off bugs to feature.
Marius Zaliukas continues his four-match suspension, while Mike Tullberg is a long-term absentee.
St Mirren welcome Mo Camara back after the former Celtic left-back was ineligible for Thursday night's Scottish Cup win over Motherwell.
Steven Robb, Stephen O'Donnell and Franco Miranda are still sidelined.
Inverness CT v Hibernian
Eric Odhiambo and Dougie Imrie will lead the Inverness attack again for this game.
Brian Kerr and Roy McBain are likely to replace the suspended Ian Black and Russell Duncan in the hosts' midfield.
Hibernian, meanwhile, have been boosted by the news captain Rob Jones has recovered from a stomach bug in time for the game.
Scotland striker Steven Fletcher is also back to full fitness after being left on the bench at Kilmarnock last weekend following precautionary scans on a knee injury.
Fellow forward Colin Nish and midfielder Denes Rosa have shrugged off knocks to make the trip north, with only full-backs Ian Murray and Kevin McCann missing out.
Rangers v Kilmarnock
Lee McCulloch has been ruled out of Rangers' clash against Kilmarnock.
The midfielder suffered a calf injury during the midweek Scottish Cup win at Forfar and could be sidelined for a couple of weeks.
DaMarcus Beasley was also injured in the clash at Station Park but has resumed training and should have recovered from the shin knock in time for the game.
Kilmarnock, meanwhile, are boosted by the return of Kevin Kyle for the trip to Ibrox as the striker returns from suspension.
But David Fernandez is still banned, while boss Jim Jefferies will make a late decision on Frazer Wright and Mehdi Taouil but is hopeful both will be fit.
Sunday
Motherwell v Celtic
Cillian Sheridan is unavailable for Motherwell's clash against Celtic as the Hoops will not allow their on-loan striker to play against them.
Paul Quinn's two-match ban does not come into effect until the following weekend so Mark McGhee has an almost-full squad to choose from.
Celtic midfielder Barry Robson will miss the trip as he is set to have an operation on a groin injury next week.
The Scotland midfielder has battled with the groin problem this season and missed the game against Rangers at Celtic Park last week after the injury flared up again in training.
Shaun Maloney will also be missing on Sunday as the striker is still out with a hamstring injury.
