I have an older AMD radion 380 that has 2 DVI, 1 HDMI and 1 display port.
I have 4 Asus 1080p monitors connected, the one on the display port is using a active HDMI adapter. All 4 can have different images or you can combine them for a virtual 4k image.
I also use the inbuilt graphics card for a 5th display.