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Four men, including a teenager, were stabbed to death in one day in separate attacks in London.
A 19-year-old youth, who has not been named, suffered multiple stab wounds in Edmonton, north London.
Later on Thursday two men in their 20s were killed in attacks a few miles away in Leyton and Walthamstow, east London.
A man in his 40s died from stab wounds after being found at the back of a disused pub in Tottenham High Road, Tottenham, north London.
Officers were alerted at about 0400 BST by a member of the public who went to Tottenham police station.
The victim was found with head injuries and slash wounds and died at the scene.
Two men and a woman were arrested nearby and are being held at police stations in north London.
Fight reported
A man aged 34 and a woman, 26, were arrested on Friday in connection with the stabbing in Edmonton.
The teenager was found injured by officers called to reports of a fight in Gloucester Road near Silver Street railway station at 1430 BST.
He became the 20th teenager to be killed in London since the start of the year.
At about 1730 BST a man in his 20s was found with a stab wound in Downsell Road, Leyton, after crashing his car.
A total of six arrests have been made
Detectives are investigating whether the victim was fleeing the occupants of a van.
Passers-by gave first aid but the man died at the scene.
One witness, who lives nearby, said: "His car door was open and he was tussled out of the car onto the pavement. He was on his back.
"A woman who looked like a trained nurse was putting pressure on his wound on his chest."
Four people arrested soon after are being questioned over the death.
A few hours later, at 2020 BST, a man aged in his 20s was attacked in St David's Court near the junction of Wood Street and Forest Road in Walthamstow. We are in this together and we all need to take responsibility
London Mayor Boris Johnson
He was found with stab wounds to the head and chest and died about an hour later.
London Mayor Boris Johsnon said: "I deeply regret that four Londoners have lost their lives in these tragic incidents. My thoughts are with the families of these men."
He added: "We need to do all we can to address the long term complex root causes of violence as well as ensuring the police are providing an effective deterrent to those who carry knives and guns.
"We are in this together and we all need to take responsibility.
"That's why we are talking to the government about bringing forward new measures next week that will help to address the underlying causes of knife violence."
A 19-year-old youth, who has not been named, suffered multiple stab wounds in Edmonton, north London.
Later on Thursday two men in their 20s were killed in attacks a few miles away in Leyton and Walthamstow, east London.
A man in his 40s died from stab wounds after being found at the back of a disused pub in Tottenham High Road, Tottenham, north London.
Officers were alerted at about 0400 BST by a member of the public who went to Tottenham police station.
The victim was found with head injuries and slash wounds and died at the scene.
Two men and a woman were arrested nearby and are being held at police stations in north London.
Fight reported
A man aged 34 and a woman, 26, were arrested on Friday in connection with the stabbing in Edmonton.
The teenager was found injured by officers called to reports of a fight in Gloucester Road near Silver Street railway station at 1430 BST.
He became the 20th teenager to be killed in London since the start of the year.
At about 1730 BST a man in his 20s was found with a stab wound in Downsell Road, Leyton, after crashing his car.
A total of six arrests have been made
Detectives are investigating whether the victim was fleeing the occupants of a van.
Passers-by gave first aid but the man died at the scene.
One witness, who lives nearby, said: "His car door was open and he was tussled out of the car onto the pavement. He was on his back.
"A woman who looked like a trained nurse was putting pressure on his wound on his chest."
Four people arrested soon after are being questioned over the death.
A few hours later, at 2020 BST, a man aged in his 20s was attacked in St David's Court near the junction of Wood Street and Forest Road in Walthamstow. We are in this together and we all need to take responsibility
London Mayor Boris Johnson
He was found with stab wounds to the head and chest and died about an hour later.
London Mayor Boris Johsnon said: "I deeply regret that four Londoners have lost their lives in these tragic incidents. My thoughts are with the families of these men."
He added: "We need to do all we can to address the long term complex root causes of violence as well as ensuring the police are providing an effective deterrent to those who carry knives and guns.
"We are in this together and we all need to take responsibility.
"That's why we are talking to the government about bringing forward new measures next week that will help to address the underlying causes of knife violence."