It is possible but i think they are all slim drives so if you wanted to use it in a desktop you would have to purchase an adapter housing and cable adapter. I don't think they cost a great deal but would prob be the only option. Unless someone knows of a full size slot loading drive.
Haven't seen a slot load 5.25" DVD since IDE. Laptop slot + 5.25" adapter, as mentioned, or external slot load (which is just a laptop drive in a case) appear to be the only options.
Some of the adapters host just the DVD drive, others support a 3.5" card reader too.
Thanks guys very much i didnt know what they were called as i was searching for wii loading dvd rom and it kept coming up with wii drvies lol.But now i know the name i shall have a gander around.